Poet’s emphasis Essay Example for Free

Poet’s emphasis Essay Although poem A contain a thematic unity but it is manifested that poet’s emphasis remained on creating a homogeneous lyrical whole instead of developing the theme in an elaborative way and in an elevated poetical manner. There is weak sentimentality that pervades the whole poem. The most important defect of the poem is that it takes into account a wide range of human roles in life and tried to culminate this human experience into the ultimate reality of death. In this attempt, poet fails to create a unifocal and forceful impact about death in the mind of the reader. Although the main though is not traditional or orthodox but poet does not present any philosophical facets, psychological impact or any other unique reflection about death. Furthermore, he is unable to manifest a great skill in making use of the arts and artifices of verse. So poem is an abject failure. Poet is unable to enjoy the visual delight of death or suffer from it pain and terror. He only changes from one role to another role with the sad demise of the first. Personal Preferences Ranking Poem F Poem C Poem D Poem E Poem B Poem A Poem F The theme is same as other poem ranked above but thematic expressions is the most important thing that elevates this poem above all other poems. Thematic expression manifested in a subtle and delicate way. So delicacy of thought mingles with height of literary expression. Subtle metaphorical attributions to seasons are another important feature of the poem. He does not rely on a single set of metaphors or symbol but he uses the financial symbols in the next quatrain to covey his message and skillfully relates it to the main theme of death and destruction. The most beautiful line of the poem is line 7 where he terminates the effect of death. He is of the view that by reproduction and regeneration, one can produce a replica of his own self, so death can not destroy him. He can conquer the death and destruction. Hence these off-spring(s) will make â€Å"thee living†. So poet has pitched the though at a higher level as compared with other poet and have utilized his language skills to create an effective expression to convey that style. Poet does not show any mystery or fascination about death. If death results in despair and terror, it also brings rest and peace. Poet negates both these conventional concept and gives a new idea that death does not terminate life if one wishes to. He can reproduce siblings like him and this is a continuation of his life. There is not magical abstraction in the poem and everything is presented and represented in clear manner with the help of concrete imagery.

Oil And Energy Industry In UAE

Oil And Energy Industry In UAE The UAE is a rich source of natural resources and it has substantially developed itself as a major player in the oil and gas industry. UAE is one of the member countries of OPEC and has been given a remarkable position in oil and gas industry all over the world by having 10% holding of total oil reserves of the world in the federation (Hellyer). The central theme of the report is to analyze the oil and gas industry of UAE country so as to analyze the contribution and impact of oil and gas industry to the GDP and economic development. Fundamentals of the Oil and Energy Industry: Historical Development of the Oil Sector around the World: The UAE is a member of the OPEC since 1967 and holds superior position in terms of the oil and gas industry with the federation holding of 10% of the total oil reserves of the world. The future holds lucrative prospects in the natural gas sector as it would cater to the manufacturing industry, generation of power and petrochemical industry by providing a source of fuel. Abu Dhabi and Dubai are the two prominent emirates responsible for the success and growth of the oil and energy sector in the U.A.E. (Energy and UAE) Importance of Oil in the UAE: The UAE is essentially an imperative provider of oil to global energy markets, by making around 10% of the overall global supply of crude oil reserves. In terms of oil exports, UAE accounts for nearly 30% of its gross domestic product becoming a mainstay in the economy. Also, UAE is emerging as a relevant consumer of energy in addition to being an important global supplier of energy. The UAE will continue to maintain its long convention of being responsible energy stewardship owing to its diversification and development of economy; acceleration of growth of additional hydrocarbon reserves and contributing significantly towards the implementation and development of other alternative sources of energy (The UAE and Global Oil Supply). Production and Reserves: Production: S.No Particulars Capacity (2011) Oil Production 3,096.34 (Thousand Barrels Per Day) Crude Oil Production 2,687.67 (Thousand Barrels Per Day) Natural Gas Production 1,811 (Billion Cubic Feet) Electricity Production 81.08 (Billion Kilowatt-hours) Source: http://www.eia.gov/countries/country-data.cfm?fips=tc Reserves: S.No Particulars Capacity (2011) 1. Oil proved reserves 97.8 (Billion Barrels) 2. Natural gas proved reserves 214 (Trillion Cubic feet) Source: http://www.eia.gov/countries/country-data.cfm?fips=tc OPEC: Background of OPEC: The Oil Producing Exporting Countries (OPEC) has been established with the sole purpose of stabilizing the prices of oil in the member countries and also to impose quotas so as to prevent the wrong and over usage of natural resources which result to their extinction sooner than expectation. As per the current information, OPECà ¢Ãƒ ¢Ã¢â‚¬Å¡Ã‚ ¬Ãƒ ¢Ã¢â‚¬Å¾Ã‚ ¢s combined reserves accounts for 1190 billion barrels of oil. According to the 2008 agreement, the production cut was imposed on the existing quota and continuing to till now. Facts reveal that the OPEC countries produce 2 million barrels a day in excess of the permitted capacity of 24.845 million barrels per day(Alternative Energy Sources Synthetic Fuels Renewable Energy). Source: (OPEC share of world crude oil reserves) Effectiveness of OPEC in achieving its Objectives: OPEC was primarily formed to keep a check on the oil prices and bridging the gap of demand and supply in the global oil market. But still the quota implementations are not followed by various countries resulting in the production of oil more than the permitted quota. According to the claims of OPEC, the fluctuation in the prices is not due to the changes in demand and supply but due to the overproduction oil other than the allotted quotas (Sousa). OPEC and Oil prices in the last 4-5 years: The following figure shows the fluctuations in the global oil prices with the adherence of OPEC rules associated with oil production: http://gailtheactuary.files.wordpress.com/2012/02/world-oil-supply-and-brent-oil-price.png Source: (Why oil prices are so high: Production shortfall, Iran concerns, and low interest rates) OPEC Quota and how it has changed over time: The OPEC quota for the production of oil for UAE is 2.23 million barrels per day. It had joined OPEC in 1967 and is the Full Member country. It produces 2798000 barrels of oil and exports 3.32% of oil in all over the world. It is ranked as the 6th largest country for the oil reserves in the world. The OPEC aims at providing the stabilization of the price of oil as regards the member countries and also the imposition of quotas as will prevent overuse of the resources which could lead to finishing up of oil reserves sooner than expected. OPEC decides the production quotas for its member countries as per the global requirement of oil which could be changed by the OPEC as per the strategic decisions pertaining to conservation, preservation, demand and supply of the oil globally (Sousa) . Source: (Sousa) Role and the influence of the UAE within OPEC: UAE become the member of OPEC countries in 1967 and acts as an active member since 1974. Since then it act as a major contributor of oil and gas industry among OPEC members. It provides the constant source of oil to the consumers of OPEC by providing approximate 2.3 million barrels of oil per day. In addition to the supply of traditional sources of energy, UAE also contributes to provide new alternatives of energy through substantial development. (UAE contributes to global energy sector: OPEC) Effect of a quota cut by OPEC: The quota cut by OPEC will affect recovery of economy in the global market. As per the evidences, the quotas cut is not helping in controlling the price issues of the oil and gas industry rather it is increasing the problem as countries tends to produce oil other than the permitted quota. The hikes in the prices of oil will increase the prices of other commodities resulting increase the rate of inflation and slowing down the economic development. (Pirog) Analysis: According to the data obtained from the Journal of Oil and Gas, the UAE is an important producer of oil, holding significantly seventh position in terms of proven resources globally. The UAE has been able to sustain its global reserves owing to the advanced enhanced oil recovery technology, EOR being implemented that leads to increase in extraction rates of several major projects in oil sector. The technology combines with high oil prices eventually to make reserves more commercially viable (United Arab Emirates Energy Data, Statistics and Analysis) The policies and procedures of oil in the UAE is primarily carried out by the government under the flagship of the Supreme Petroleum Council, through ADNOC operating at every level of oil and energy sector in UAE. The government has pushed back several its plans to increase capacity in order to increase the production capacity of crude oil (United Arab Emirates Energy Data, Statistics and Analysis). UAE economy, underpinned by its wealth in oil, has recorded a steady growth over the last couple of years. In terms of oil GDP, the figures have doubled from AED 387.8 billion to AED 934.3 in last assessment year. Recent Development in Oil Sector of UAE: With the advent of Habshan-Al-Fujairah pipeline for the purpose of carrying oil from oil fields of Abu Dhabi to the exporting port has been essentially proved as a strategic and economic advantage for the overall sector of the country. The pipeline extending 350 kilometers from oil fields and with this the country will be able to export 1.5 million oil barrels in a single day. (Asoomi) Alternatives to Oil Industry: Keeping in mind the limited availability of fossil fuels and to prevent its overuse to meet the worldà ¢Ãƒ ¢Ã¢â‚¬Å¡Ã‚ ¬Ãƒ ¢Ã¢â‚¬Å¾Ã‚ ¢s growing energy demands, various alternatives to energy sources have been identified. Unconventional alternatives Liquefied Natural Gas (LNG) is the upcoming form of natural gas which provides an excellent alternative to conventional natural gas usage. GTL is not only a beneficial alternative but is also environment friendly as there are no harmful emissions on its combustion. Oil sands also provide a source of the extraction of oil from it and its use is significantly increasing with time. The only limiting factor is the increasing cost of setting up the required infrastructure and cost of mining and extraction of oil from it. However the oil sands are accompanied by noxious fumes which are contributing to the global warming issue (Alternative Energy Sources Synthetic Fuels Renewable Energy). Bio-fuels have been the outcome of recent developments in scientific researches. In this the organic matter is used to derive hydrocarbon based fuels such as Biodiesel, ethanol, etc. The conventional sources of energy include solar, wind and hydro energy all of which are renewable and 100% environment friendly. (Alternative Energy Sources Synthetic Fuels Renewable Energy) . Recent Developments: UAE has been involved in many new projects including increase in crude oil production to 4 million barrels per day by 2020. This would results to the increase in 40% from current capacity. The major upcoming projects include Bourouge complex expansion projects and the Habshan Gas Complex Expansion. UAE is planning to invest $ 6 billion to develop the infrastructure of oil and gas industry. Abu Dhabi government is planning to invest $ 20 billion in Masdar to develop alternative energy resources to oil and gas industry. (Oil Gas Directory Middle East) Future Scenarios: Future plans of the OPEC and the UAE Oil sector and their effect on the Economy: To promote fair and stable oil prices and strategies of capacity expansion. To examine the technological, economical, political growth and development pertaining to the oil energy and other important sectors. To encourage the oil consuming nations for the enhancement of investment associated with downstream sector. To promote the technological development in order to addressing the issues pertaining to the climate changes. To minimize the bad impact of environmental issues on the developing countries which exporting fossil-fuel (OPEC Long-Term Strategy). Impact of Oil and Non-Oil Alternatives on the future of the UAE: Oil sector is one of the essential components contributing towards the countryà ¢Ãƒ ¢Ã¢â‚¬Å¡Ã‚ ¬Ãƒ ¢Ã¢â‚¬Å¾Ã‚ ¢s economy with special economic consequence on rate of inflation, consumer spending and eventually auto sales of the country. The boom in the oil sector is bringing a gradual shift from trading and fishing to oil sector, making UAE depending heavily on petroleum and crude oil as a main source of foreign exchange earnings. The real output growth of the country is increasing owing to the rising hydrocarbon production and other non oil sectors, especially trade, logistics and services eventually bearing a relative economic growth revival. Recommendations: It is recommended to grab the opportunity from joint ventures to develop the sources not only in Dubai but also all over the UAE. Need to pay attention to other prevailing sectors such as banking, real state, telecom and aviation in order to increase the GDP and economic development. Identification of better source of material and labor should so as invest in major projects along with the implementation of Green initiatives Conclusion: Oil and Energy is a certainly a very important sector of the world that nourishes and contributes as a largest part to the GDP of the country. The production of oil leads to the production of various by-products and therefore the oil producing and exporting companies in UAE earns great revenue. At the same time, country earns most of its export earnings from oil and gas sector. On the other hand, due to emergence of other non oil sectors and slow economic growth, the sector is now facing several challenges including the challenge of diversification and privatization.

Identification of Prednisolone Acetate

Identification of Prednisolone Acetate IDENTIFICATION AND CHARACTERIZATION OF DRUG The procured prednisolone acetate was identified and characterized based on the following parameters. ORGANOLEPTIC PROPERTIES For the selected samples (drug + excipients) the following organoleptic properties were studied using descriptive terminology. Those were nature, odour and colour PARTITIONING BEHAVIOR OF PA IN DISTINCT LIPIDS: The percent partition coefficient of Prednisolone acetate in selected lipids was analyzed as elucidated elsewhere. On the part of the study/briefly, a mixture composed of melted lipid and 10mL of de-ionized water to this 10mg of PA was added. The resultant mixture was agitated reciprocally for one hour maintained at 50C above the lipid melting point. The quantity of lipid utilized was mentioned in table 1. The resultant dispersion was allowed to cool. Upon making cool both phases were separated by ultracentrifugation ( ) at 15,000 rpm and filtered. The drug content in supernatant was analyzed spectrophotometrically (240nm). The percent partition coefficient was predicted as follows: % partition = w1-w2/w1 x 100 W1 = Amount of drug added W2 = Amount of drug in aqueous phase DETERMINATION OF MELTING POINT PA melting point was determined by capillary method. Theoritical value was compared with practical value. LOSS ON DRYING This method measures the weight of volatile compounds or moisture of any kind which can be driven off under the specified conditions. Stoppered, shallow glass bottle was weighed and dried under the specified conditions. 2 grams of sample was accurately weighed and transferred to dried bottle. Then the loaded bottle was in electric oven, removed stopper and left near by it in drying chamber at 1050c for 2 hours at atmospheric pressure. After two hours the glass container was taken out from oven and weighed it again. The following formula was used for the calculation of LOD % LOD = Mass of test specimen – Mass of loaded bottle after drying/ Mass of sample – Mass of empty glass bottle IR SPECTROSCOPY OF DRUG Thin pellet was prepared using potassium bromide and drug in a ratio of 100:1 respectively. The molecular state of prednisolone acetate was studied using FTIR spectrometer. DSC PA thermogram was obtained in DSC 200 F3 Maia using empty aluminum pan as reference. The accurately weighed 2mg of sample was exposed to temperature range 0oc – 500oc under nitrogen atmosphere (flow rate: 60ml/min) at a heating rate of 10oc/min. UV-VISIBLE SPECTROPHOTOMETER (WAVE LENGTH SELECTION) 10mg of drug was dissolved in 100mL of simulated nasal electrolyte solution (SNES) which results in 100Â µg/ml concentration solution. From this 25 Â µg/ml was prepared. A few ml of this solution is transferred into cuvette (path length of 10mm cell) and scanned in the wave length range of 200-400nm against SNES as blank in double beam UV-Vis spectrophotometer. COMPATIBILITY STUDIES OF LIPID AND SURFACTANT MIXTURE The selected mixtures of lipid and surfactant, lipid and cosurfactant were blended at different ratios like 1:1, 2:1, 3:1 and 4:1. The blend was mixed for 10min and mixtures were observed visually for clarity (or) absence of turbidity. SOLUBILITY STUDIES OF PREDNISOLONE ACETATE The solubility of drug was estimated in different buffers, lipids, surfactant mixture ratios and solvents which are essential during development of formulation. IN DIFFERENT LIPIDS Test tube method was used for analysis of PA solubility in several solid lipids. To determine it 10mg of drug was placed to a test tube and temperature was maintained 50c higher/above the lipid melting point. The lipid was added an increase in quantity of 10mg till PA was solubilized completely and quantity of solid lipid needed for dissolution of drug was determined. IN VARIOUS RATIOS OF SURFACTANT MIXTURE The solubility of prednisolone acetate was investigated in numerous surfactant and co-surfactant ratios range from 1:1 to 4:1(Sur: Co-sur- Sur: Co-sur). Solubility studies were analyzed by adding an excess amount of PA in a 20 mL screw capped containers consisting different ratios of 10mL of each surfactant mixture. The mixtures were vortexed on orbital shaker at 50 rpm for 2 days at 37oc to enhance solubilization. After attaining equilibrium the samples were ultracentrifuged at 12,000 rpm for 30 min to separate the undissolved drug (PA) and supernatant was filtered through whatman filter paper. HPLC grade methanol was used to dilute the supernatant sample and these were filtered with 0.45 Â µm membrane filter. Then, the diluted samples were used to quantify the PA by UV-Vis spectrophotometer at 240nm. IN DIFFERENT SOLVENTS AND BUFFERS The excess quantity of drug was added to 10ml of different solvents includes pH 6, 6.4, 7, 7.4, 8 phosphate buffer, ethanol, double distilled water and methanol in a 25ml volumetric flask. Then flasks were properly capped and agitated at 37Â ±0.5oc in orbital shaker for 48 hours. The samples were filtered through whatman filter paper. The filtrate was diluted using suitable diluent and again filtered using 0.45Â µm membrane filters. Then samples were analyzed at 240nm by UV spectrophotometer. ds COMPATIBILITY STUDIES OF DRUG AND EXCIPIENTS The selected excipients were listed in GRAS (Generally recognized as safe by FDA) and used in various pharmaceutical formulations. Which are procured from reputed national and international manufacturers. The study of compatibility between drug and excipients was followed as. DSC METHOD : Differential scanning calorimetry was carried out using DSC F3 Maia instrument to analyze the melting transitions and heat capacity changes of drug alone and physical mixtures. The physical mixtures were prepared by triturating the PA and excipients in the ratio of 1:10 in a mortar for five minutes. The samples (5mg) were loaded in aluminum pans, sealed hermitically and heated under inert gas i.e. nitrogen at the flow rate of 60mL /min at 10oc/min heating rate ranges/set from 0 oc to 500 oc. The standard reference was an empty alumina crucible. The above said parameters/ conditions were used to analyze the samples and thermograms of DSC recorded/ data recorded using proteus software. Samples analyzed for DSC and FTIR were followed as The above physical mixtures compatibility was also found by adding desired quantity of mixture in glass vials and subjected to 60 oc for 30 days. The physical appearance of mixture was not changed at the end of the study. FTIR API was mixed with different excipients separately and spectral analysis was carried out using FTIR to study the placebo interference. The pressed pellet method was used to study the FTIR spectral studies. In this analysis, test-excipient mixture and potassium bromide were taken in the ratio of 1:100. The mixture when placed in hydraulic press under vacuum pressure of 800 mPa resulted in the formation of compressed thin transparent disc. The molecular states of samples were traced/determined between 4000-1000 cm-1 using Bruker FTIR spectrophotometer. The obtained IR spectra’s were evaluated to determine interactions. The data mentioned in table . Graphical representation shown/given in figure . METHOD DEVELOPMENT OF PREDNISOLONE ACETATE A survey of literature had showed that different instrumental methods like UV, HPLC, and HPTLC were reported for the quantification of prednisolone acetate. The present research work focused on development of UV spectroscopic method for dissolution samples estimation and HPLC for drug content, dissolution and bioanalytical quantification. Preparation of simulated nasal electrolyte solution(SNES) A solution of SNES was prepared by adding 8.77g of sodium chloride, 2.98g of potassium chloride, 0.45g of calcium chloride in water and finally made the volume to 100 mL resulting in pH 5.5. UV-Vis METHOD Stock solution prepartion 100mg of test sample was accurately weighed, transferred into 100 mL volumetric flask. To this little quantity of ethanol was added to dissolve the sample and made the volume up to 100ml using SNES (pH5.5) to get 1000Â µg/ml concentration stock solution. Prepartion of Linearity plot From the above stock solution 0.5, 1, 1.5, 2, 2.5ml were transferred in separate 100 mL volumetric flasks and diluted up to the mark with SNES to produce 5, 10,15, 20, 25 Â µg/ml concentrations respectively. The absorbance of each concentration was recorded in 1cm cell with SNES as blank at 240nm using Shimadzu, UV spectrophotometer. This procedure was done over for 3 times. With concentration on x-axis and absorbance on y-axis a calibration graph was constructed. Inter day and intraday studies were carried out for the determination of accuracy and precision using 1,5,10 Â µg/ml standard concentration solutions. The readings were tabulated in table and figure . HPLC METHOD PSEUDOTERNARY PHASE DIAGRAM CNSTRUCTION To construct the phase diagrams (prosim 1.0 software) hot water titration method was used. Through these phase diagrams components concentration range was investigated which can be results in existence of large microemulsion area. The surfactants used were tween 80,60,20, Cremophor RH40 and cosurfactants were ethanol, PEG 400. The surfactant and cosurfactants was blended in fixed weight ratios such as 1:1, 2:1, 3:1, 4:1. Solid lipids were tristearin, tripalmitin, GMS, stearic acid, Palmitic acid, cetyl palmitate. Lipid was melted at 65oc to this required quantity of hot surfactant mixture was added followed by adding water drop by drop to mixture under stirring with magnetic stirrer until turbidity formed. DEVELOPMENT OF DRUG LOADED MICROEMULSIONS From each phase diagram ME area was calculated by using CAD software. From each lipid, based on the above area values highest area of phase diagram was selected then the ME formulations were taken at required component weight ratios. The procedure of desired microemulsion was as follows. Required amount of lipid heated at 65oc in this 10mg of PA was dissolved. Heated SM and water was added to the above melted lipid mixture under stirring. The mixture was categorized as microemulsions if melt was appeared clear. Then mixture was considered as microemulsion. SOLID LIPID NANOPARTICLES PREPAR TION USING PROBE SONICATOR PA SLNs were prepared by hot lipid microemulsion technique. Drug loaded ME procedure was aforementioned in page No . 2mL of loaded ME was taken in a glass syringe using 22 gauge needle. Then it was added dropwise to a 3mL of cold de-ionized water under ice bath (2-4oc) and sonicated by probe sonicator for different time periods (5, 10, 15 min) specified by box behnken design at 200w amplitude to solidify the SLNs. The tip diameter of probe 8mm was dipped in liquid of 10mm leads to reflecting upwards and wave moving downwards. DRUG CONTENT (ASSAY) DETERMINATION 1 mL of solid dispersion from the formulations selected for evaluation was transferred into 10mL volumetric flask and diluted up to the mark with methanol. Then the solution was subjected to ultracentrifugation for 15 min at 10,000 rpm. Then the supernatant was aspirated, filtered, suitably diluted and measured the absorbance at ÃŽ »max 243nm. The results given in Table HR TEM The surface morphology of prepared SLNs like particle size, particle shape and aggregation were analyzed by HRTEM operating at 120kv voltage. The samples were diluted properly, stained by 2% phosphotungistic acid. A drop of aqueous dispersion was placed /mounted on carbon coated 400mesh copper grids which is to be allowed for 5 min to dry the nanoparticles on grid before examination under IR lamp/AIR DRY and TEM images were recorded with mangnification range from 11500-50000x. PARTICLE POTENTIAL, SIZE AND POLYDISPERSITY INDEX(PI) For the prepared SLNs the mean particle size, zeta potential and PI were performed by dynamic light scattering (DLS) with a zetasizer Nano – ZS90 (Malvern application center, banglore), model ZEN 3690 and equipped with 4mW, 633nm He-Ne laser. The measurements were made at the following conditions: Refractive index of medium: 1.330 Dielectric constant value: 78.5 Viscosity of dispersion medium: 0.8872 Temperature: 250c Then the samples (100Â µl) were diluted to 1mL with de-ionized water to prevent multi scattering and transferred in to a disposable zeta cuvettes to record the particle size. The size measurement angle was 900. The PI value was used to determine particle size distribution. The same instrument was used for the determination of zeta potential using an laser Doppler electrophoresis technique. Zeta potential value was calculated from the mean mobility of electrophoresis values by henry equation. The measurements were done in triplicate. ENTRAMENT EFFICIENCY % EE of the PA was studied by determining the unentrapped drug concentration in supernatant layer(aqueous layer). Accurately measured 5ml of (equivalent to 10mg of PA) nanoparticle dispersion was transferred to eppendorf centrifuge tubes and centrifuged at 15000 rpm for 30 min at -3oc using ultra cooling centrifuge. Then the supernatant was separated, diluted appropriately using SNES and filtered using 0.45 Â µm membrane filter. The filtered samples were estimated by using UV spectrophotometer at ÃŽ »max 240nm against blank. Encapsulation efficiency was determined using the equation. % EE = Quantity of drug added – weight of drug in aqueous phase/ mass of drug added x 100 INVITRO DIFFUSION STUDIES Dialysis bag method was used to determine invitro diffusion release profile of PA and using a USP dissolution apparatus II. Before using dialysis membrane was soaked in SNES for 12 hours and the molecular cutoff of membrane was between 12000-14000. The following conditions were used to carry out diffusion studies. The run speed of paddle: 100 rpm Diffusion medium: SNES (pH 5.5) Volume of medium: 500mL Temperature: 37Â ±0.5oc Time intervals: The SLNs dispersion containing the 10mg/5mL(amount equivalent to one dose of drug) was transferred in dialysis bag and tied at both ends. Then the it was suspended in the receptor compartment containing SNES pH 5.5. An aliquot of 5ml samples were removed at fixed time points from receptor medium. The same volume of fresh buffer was replaced after every time point to maintain constant buffer volume. The fresh buffer was also maintained at the same temperature(37Â ±0.5oc ) similar to sample. The PA concentration was estimated using UV-Visible spectrophotometer at 240nm against blank (SNES). The final optimized sample concentration was further determined by HPLC. The selected formulation results data were shown in Table and graphical representation in figure RELEASE KINETICS The release mechanism of drug from solid lipid nanoparticles were analyzed and determined by fitting the invitro release data to different kinetic models includes Zero, first order, higuchi and peppas-korsemayer. References UV-VISIBLE E.G.C. Clarke, Isolation and Identifeation of Drugs, volume 1 , The Pharmaceutical Press, London, 1978, p. 270

The Fish Essay -- essays research papers

â€Å"The Fish†   Ã‚  Ã‚  Ã‚  Ã‚  Poems to me are an expression of a person’s outlook on a particular scene or subject. By reading a poem a person can be enlightened and take an understanding of what they are actually reading. In â€Å"The Fish†, I personally was caught up in all the excitement because I know what it feels like to catch a really gigantic fish. This poem, to me, shows an outlook on nature that I have always been accustomed to. In writing poems there is a whole category of tools and techniques you can use to make the poem great instead of mediocre. In this poem, to me imagery plays a very big role. When you read the poem the imagery lets you not only think about what you are reading but also it lets you actually see it in your head. Another tool used in the poem is personification. It can help the author do so much more explaining than the usual. Personification in this poem is just as important as the use of imagery is. Also, the ideas/themes of this poem are very cru cial as well to make it a very good poem. When Elizabeth Bishop put all of these tools together she made â€Å"The Fish† what it is today, a great poem.   Ã‚  Ã‚  Ã‚  Ã‚  The use of imagery in this poem had to be used in just the right way. If it was not used properly then the poem could have lost all meaning and understanding, making the poem pretty much useless. When Bishop uses lines like this the imagery is shown very well. â€Å"Here and there his brown skin hung in strips l...

Kmart SWOT Essay -- essays research papers

Kmart started off on the right foot back in 1899 and was a major player in supplying goods to the consumers from their small five and dime stores. From there they started to expand, they were a provider of low-cost merchandise but once the competition (Wal-Mart and Target) started opening they started loosing the fight. Since that time they have been through many changes and many hard times. By 1962 they started opening full line discount stores which continued to help the company succeed. From 1980 - 2002 five different CEOs ran the company. Some of their strategies were focused on the same track as the one before them while others had to change direction entirely in order to fight to turn the company around. Kmart has suppliers that they order their goods from so they can keep their shelves stocked. They do not make any of their own products however they do try to differentiate themselves by selling exclusive brands that include Thalia Sodi, Jaclyn Smith, Joe Boxer, Martha Stewart , and Sesame Street. Kmart ¡Ã‚ ¦s strategy has changed a few times since they started out and may continue to change in order to succeed. They have faced bankruptcy in the past and have fought to continue to compete against their competitors. Kmart has many competitive and environmental forces impacting the industry today. As all organizations do some or these forces are opportunities for them while others are threats to the organization. A few of the forces are their rivals or competitors, the substitutes that can be used, and the new entrants into the market. The main rivals among the merchandising companies are Wal-Mart, Kohls, Family Dollar and Target among many more. Wal-Mart and Target are their main rivals, this is because Wal-Mart is known for their niche as having the lowest prices and Target is known for their fashions and home furnishings both of these items Kmart tries to compete against. Also buyers see Kmart as a discount store which doesn ¡Ã‚ ¦t stand when other competitors have lower prices. Kmart ¡Ã‚ ¦s customer service and available products are two other items that Kmart fails to be a strong competitor in against these rivals. Therefore, the rivalry among the merchandising stores is a strong competitive force in this market. Another external force that affects the market is substitutes. Substitutes are the items a customer can buy to replace the items they purch... ...o the picture. By getting rid of their food items they would also have more room on the shelves to stock the much more requested items that customers want. Since Kmart is up against a couple well known companies they are going to need to stand out. They have their exclusive brands which is great if that is what the customer wants. They need to really push these items by marketing (TV spots and newspapers) so the consumer feels they need to have these items. They also need to put standards in place so that anytime research is done there is a project team put together to implement what changes need to be completed. Their strategy to win back the customer is failing because they are not implementing the needed changes. Instead they are closing down stores and not remodeling the ones that are still in business. They are loosing the market share to both Target and Wal-Mart because they are so focused on how to make another buck that they are not focusing on what really matters, the cu stomers. Until the customers are satisfied with the stores product (being on shelves), the service they receive and the location and shape of the stores they will not return as loyal customers to Kmart.

Hip Hop Childrenswear

The style express how active they were, and this collection adapted the idea of free, colorful, youthful but still comfortable to wear for children. This collection uses a lot of prints, and bright colors but still looks good on Fall/Winter season for children. Last but not least, I hope this collection can give inspiration and knowledge about the world-changing movement, hip hop. THE BEGINNING OF HIP HOP Hip hop started to began in South Bronx, New York city, around late sass. At that time black (skinned) people that mostly African-American was living as a group of minorities in America.They can't get the same facilities that white people can easily et. One of the story was, black (skinned) kids had to walk to school even their school has a far distance. But, for the white children, they can use the public transportation like buses. Then to express the injustice, they show it through creative ways. One of the hip hop pioneer is DC Cool Here (Clive Campbell). He is one of the people who developed hip hop music before later spread out through the world. Fig 1. DC Cool Here (Clive Campbell), 2008 At that time, hip hop also helped youngsters.Instead of fighting with the street gangs, they spend their time dance battling. Then Africa Bumboat founded the Zulu Nation, it's a confederation of street-dance crews, graffiti artists, and rap musicians. After that, hip hop movement gained more and more media attention, Billboard magazine printing an article titled â€Å"B Beats Bombarding Bronx†, commenting on influential hip hop figures like DC Cool Here. Hip hop still developing, until now, there are female hip hop artists too like Nick Mina] and Queen Latish. They also protesting the graphic hip hop lyrics depicting rape and violence against women.Rap is also a part of hip hop. Rap became a way for artists to spread political and social messages to people who still unaware about the life of African-American people. Fig 2. Africa Bumboat (Kevin Donovan), founder o f Zulu Nation, 2012 Later then, Hip hop started to spread out to the world â€Å"the center of a mega music and fashion industry around the world† that crosses social barriers and cuts across racial lines. 4 HIP HOP INFLUENCE ON FASHION † Hip- hop has become a lifestyle that's no longer Just associated with African- Americans or Latino, it has a global reach. – Task Lewis, Ph. D. '09, assistant professor of fiber science and apparel design in the College of Human Ecology. Hip Hop movement is no longer associated only with one group of people, the hip hop style adapted to the fashion world, where now people can wear tracksuits, sporting gear, oversized T-shirts, overalls and combat boots. In sass, this look was adopted by major fashion labels, becoming part of the mass culture. Also, the hip hop subculture embraced the country club luxuries of more venerable brands, which features not usually marketed to urban youth.In sass, one of the hip hop endorsement in fashi on industry was done by Ideas, which shell shoe get popularized by group Run DMS. Ideas reportedly paid Run DMS $1 million for the deal. From there, hip hop's influence in fashion continued to grow with corporations, and later with hip hop artists creating their own fashion labels. Ideas ads, Run DMS Fig 3. Michael Jordan with Nikkei Air Jordan, 1984 Then in 1984, Michael Jordan and Nikkei collaborated to create the Air Jordan basketball shoe. These shoes would become the most sought-after accessory since the Hermes Firkin.While the price point was high ($100 at the time), it did not stop young men from lining up. Nikkei still sells the Air and releases retro versions of the sneaker that sell out in hours across the globe. 6 Hip hop in early development in clothing was embraced by American designers, Ralph Lauren and Tommy Hellfire. Men would buy clothes a few sizes bigger, adapted the baggy silhouette rappers were known for both on and offstage. Russell Simmons, one of hip hop prod ucer, capitalized on this trend by creating Path Farm clothing, the first hip hop clothing label.This revolutionized the fashion world, and many would follow in his footsteps, including Sean â€Å"Daddy† Combs and rappers Newly and 50 Cent. Path Farm Clothing Fig 4. Russell Simmons, 2013 After that, hip hop style spread out more and more through any part of the world, to he Paris and Tokyo streets. Designers took note of this and began adding a dose of hip hop to high end collections, such as the 1991 Channel collection, where Karl Laagered showed piles of gold Jewelry on models. In sass, many hip hop artists and executives started their own fashion labels and clothing lines.This ready to wear collection is focused on children at their teenage (5-7 years old) whose parents living in upper-middle class. Focusing on parents who want to dress up their children based on unique street style but still comfortable to wear. Children who also fond of fashion and to look different amon g the others. All looks in this collection can be worn daily, at any occasions. In this childlessness project, I have learned that hip hop style which usually worn by adults can also adapted to kids garments.Since its childlessness, all of the garments in this collection use comfortable material and easy to manage. From using the denim fabric, I also learned that many fabric manipulations can be made, such as making pleats from a piece of denim or ripped it. And by using subtle colorful fabric, it give more fun feeling to this collection. Overall, I have improve my knowledge in how to get theme, how to research on the theme and how to realizing my collection room the design stage until finish. BIBLIOGRAPHY Resellers, D. (2012, August 15).

Compare and Contrast on Fibers Essay

As nutrition labeling becomes essential throughout the world, it is recognized that a single definition of fiber may be needed. New products are being developed or isolated that behave like fiber, yet do not meet the traditional requirements of fiber, either analytically or physiologically. Without an accurate definition of fiber, compounds can be designed or isolated and concentrated using available methods without necessarily providing beneficial health effects, which most people consider to be an important attribute of fiber. Most of us are familiar with the terms â€Å"soluble fiber† and â€Å"insoluble fiber† but what is the actual difference? Soluble fibers bind with fatty acids and slow digestion so blood sugars are released more slowly into the body. These fibers help lower LDL cholesterol and help regulate blood sugar levels for people with diabetes. Insoluble fibers help hydrate and move waste through the intestines and control the pH levels in the intestines. These fibers help prevent constipation and keep you regular. The three most commonly used fibers are dietary, functional, and total fibers. Dietary Fiber consists of non-digestible carbohydrates and lignin that are intrinsic and intact in plants. Functional Fiber consists of isolated, non-digestible carbohydrates that have beneficial physiological effects in humans. Total Fiber is the sum of Dietary Fiber and Functional Fiber. Dietary fiber comes from the portion of plants that is not digested by enzymes in the intestinal tract. Part of it, however, may be metabolized by bacteria in the lower gut. Different types of plants vary in their amount and kind of fiber. Dietary Fiber includes pectin, gum, mucilage, cellulose, hemicellulose and lignin. Pectin and gum are water-soluble fibers found inside plant cells. They slow the passage of food through the intestines but do nothing to increase fecal bulk. In contrast, fibers in cell walls are water insoluble. These include cellulose, hemicellulose and lignin. Such fibers increase fecal bulk and speed up the passage of food through the digestive tract. Dietary fiber may help reduce the risk of some cancers, especially colon cancer. This idea is based on information that insoluble fiber increases the rate at which wastes are removed from the body. This means the body may have less exposure to toxic substances produced during digestion. Dietary fiber is found only in plant foods such as fruits, vegetables, nuts and grains. The form of foods may or may not affect its fiber content. Canned frozen fruits and vegetables contain just as much fiber as raw ones. Other types of processing may reduce fiber content. Drying and crushing, for example, destroy the water-holding qualities of fiber. The removal of seeds, or peels also reduces fiber content. Whole tomatoes have more fiber than peeled tomatoes, which have more than tomato juice. Likewise, whole wheat bread contains more fiber than white bread. Functional Fibers are isolated, non-digestible forms of carbohydrates that have been extracted from starchy foods or manufactured from starches or sugars. Unlike dietary fibers which are consumed in whole foods like vegetables, grains and legumes. These added substances are considered fiber because, like dietary fiber, they resist digestion and perform some of the same functions when eaten. Functional Fiber may have some of the benefits of naturally consuming dietary fiber, such as helping to prevent constipation or lowering blood glucose levels after meals, but in contrast lack nutrients and phytochemicals that come with fiber found in whole foods. Functional Fibers include gums, pectins, polydextrose and inulin. Inulin and polydextrose are water-soluble fibers as well as pectin and gums found in dietary fiber. Inulin is one functional fiber that is now being added into many food products enabling an excellent source of carbohydrates for probiotic organisms populating the lower portion of the gastrointestinal system. Such fibers may increase beneficial bacteria in the gut, enhance immune function, add bulk to stools, and help prevent constipation. Most nutritionists encourage getting fiber from whole foods that we eat because they contain many other healthful plant compounds. However, if you don’t get enough fiber in your diet (25-38grams daily) added functional fibers can help fill in the gap. On food labels, functional fibers are usually included in the grams of dietary fiber. Eating a wide variety of fibers is the ideal solution to gaining all the health benefits. Total fiber is the sum of dietary fiber and functional fiber. It’s not important to differentiate between which forms of each of these fibers you are getting in your diet but that the total amount is moderate. Eating too much fiber (more than 50-60 grams of fiber a day) may decrease the amount of vitamins and minerals your body absorbs. To add more fiber to the diet, an individual can increase the amount eaten gradually, this gives the stomach and intestines time to get used to the change. In addition, fiber supplements could easily lead to excess, which may cause intestinal discomfort thus, adding fiber to the diet with the addition of fiber rich foods is a safer route. Eating too much fiber too quickly may cause gas, diarrhea, and bloating. Excessive use of fiber supplements is associated with greater risk for intestinal problems. Some of the benefits from a high fiber diet may be from the food that provides the fiber, not from fiber alone. For this reason, it is best to obtain fiber from foods rather than from supplements.